I have very blister-prone feet. Blood blisters, regular ones, you name it. Here are some tips: One, and most important: check shoe size. Your feet swell more on longer runs. What fits at 10 miles does not at 20. Two: check the material on the toe box to see if it's rubbing you wrong and if so avoid that configuration in your next shoe purchase. I had a pair that gave me blisters because they had more leather and less mesh than most shoes across the toes (specifically the area where the shoe creases across the top as your foot flexes). Three: try vaseline, Bodyglide, stick deodorant, or spray deodorant. Different ones work for different people. Four: don't try to toughen your feet, instead keep callouses down! Otherwise callouses move back and forth like a rock in your shoe and create new blisters under themselves. Nasty. I suggest about every two weeks that you sand the callouses off, smear vaseline on your new skin, and go to bed with socks on. Good luck.